Table 1 Kinetic parameter values. Population kinetic parameters for infused Ringer’s solution in 160 conscious and anesthetized subjects. Typical values (tv) for the fixed parameters for all subjects, followed by individual-specific covariates are shown
From: Accelerated lymph flow from infusion of crystalloid fluid during general anesthesia
Kinetic parameter | Covariate | Best estimate | 95% CI | CV% | P-value |
|---|---|---|---|---|---|
Fixed | |||||
tvVc (L) | 3.21 | 2.90–3.54 | 5.4 | ||
tvk12 (10− 3 min− 1) | 113.0 | 77.1–148.0 | 16.1 | ||
tvk21 (10− 3 min− 1) | 118.8 | 58.3–179.4 | 26.0 | ||
tvk23 (10− 3 min− 1) | 24.0 | 20.1–28.0 | 8.4 | ||
tvk32 (10− 3 min− 1) | 64.0 | 37.8–90.3 | 20.9 | ||
tvk10 (10− 3 min− 1) | 20.7 | 17.5–24.1 | 8.1 | ||
Covariates | |||||
k10 | MAP (mmHg) | 2.10 | 1.52–2.68 | 14.1 | 1.6 × 10− 13 |
Vc | Body weight (kg) | 0.75 | 0.56–0.95 | 13.4 | 3.5 × 10− 8 |
k10 | General anesthesia (no/yes) | -1.67 | -1.98 to -1.37 | -9.4 | < 1 × 10− 3 |
k21 | Hb-Alb dilution difference | 3.08 | 2.00–4.15 | 17.8 | 5.9 × 10− 5 |
k12 | Hb-Alb dilution difference | 2.86 | 1.85–3.69 | 18.0 | 1.1 × 10− 12 |
Vc | Hb-Alb dilution difference | -1.06 | -1.56 to -0.55 | -24.4 | 1.3 × 10− 53 |
k21 | Ongoing infusion (no/yes) | -0.50 | -0.70 to -0.30 | -20.7 | 3.0 × 10− 19 |
k23 | Irrigating fluid (no/yes) | 1.22 | 0.85–1.60 | 15.6 | 2.4 × 10− 5 |
k23 | Ongoing infusion (no/yes) | -7.60 | -8.49 to -6.70 | -6.0 | 2.6 × 10− 12 |
Vc | Sex (male/female) | -0.50 | -0.62 to -0.38 | -12.1 | < 1 × 10− 3 |
k21 | General anesthesia (no/yes) | -0.44 | -0.61 to -0.29 | -18.2 | < 1 × 10− 3 |