Fig. 1
From: Accelerated lymph flow from infusion of crystalloid fluid during general anesthesia
(A) Schematic drawing of the used kinetic model. (B) Conditional weighted residuals (CWRES) versus the plasma dilution as predicted by the kinetic model without covariates. Good model specification is indicated by random distribution of the data around the individual predictions and over time, and by the few data points > ± 3 standard deviations. (C) Predictive check. The confidence limits for the plasma dilution as given by the observed data and when these data were recreated by 1,000 simulations using the kinetic parameters. The hatched pattern is due to irregular sampling frequencies between studies. (D) The measured plasma dilution versus the model-predicted plasma dilution when all covariates were considered (N = 2,408). The line of unity is shown in red. (E) Same plot for the urinary excretion (N = 454)