Table 2 GRADE evidence profile of all outcomes
No of studies | Study design | Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
RoB | Inconsistency | Indirectness | Imprecision | Other considerations | Ciprofol | Propofol | Relative (95% CI) | Absolute (95% CI) | ||||
Successful induction rate | ||||||||||||
6 | RCT | not serious | not serious | not serious | not serious | publication bias strongly suspecteda | 388/388 (100.0%) | 324/324 (100.0%) | RR 1.00 (0.99 to 1.01) | 0 fewer per 1,000 (from 10 fewer to 10 more) | ⨁⨁⨁◯ Moderate | Critical |
Time to onset of successful induction | ||||||||||||
6 | RCT | not serious | seriousb | not serious | not serious | none | 388 | 324 | - | MD 3.08 s higher (0.93 lower to 7.09 higher) | ⨁⨁⨁◯ Moderate | Critical |
Time to disappearance of eyelash reflex | ||||||||||||
3 | RCT | not serious | seriousc | not serious | not serious | none | 208 | 208 | - | MD 0.55 s higher (1.5 lower to 2.6 higher) | ⨁⨁⨁◯ Moderate | Critical |
Overall estimated mean in BIS | ||||||||||||
6 | RCT | not serious | not serious | not serious | not serious | none | 388 | 324 | - | MD 3.79 lower (4.57 lower to 3.01 lower) | ⨁⨁⨁⨁ High | Critical |
Time to full alertness | ||||||||||||
3 | RCT | not serious | not serious | not serious | not serious | none | 180 | 116 | - | MD 0.67 min higher (0.03 lower to 1.36 higher) | ⨁⨁⨁⨁ High | Critical |
Incidence of hypotension | ||||||||||||
6 | RCT | not serious | seriousb | not serious | not serious | none | 106/388 (27.3%) | 127/324 (39.2%) | RR 0.63 (0.42 to 0.94) | 145 fewer per 1,000 (from 227 fewer to 24 fewer) | ⨁⨁⨁◯ Moderate | Important |
Incidence of arrhythmia | ||||||||||||
6 | RCT | not serious | not serious | not serious | not serious | none | 44/388 (11.3%) | 41/324 (12.7%) | RR 0.81 (0.55 to 1.21) | 24 fewer per 1,000 (from 57 fewer to 27 more) | ⨁⨁⨁⨁ High | Important |
Incidence of injection-site pain | ||||||||||||
6 | RCT | not serious | seriousa | not serious | not serious | none | 34/388 (8.8%) | 146/324 (45.1%) | RR 0.26 (0.14 to 0.47) | 333 fewer per 1,000 (from 388 fewer to 239 fewer) | ⨁⨁⨁◯ Moderate | Important |