Efficacy and safety of esketamine combined with propofol for curative endoscopic resection in colorectum: a prospective, randomized controlled trial

Table 3 Sedation-related adverse events

Events	Fentanyl (n = 79)	Esketamine (n = 81)	p
Oxygen desaturation	20 (25.3)	12 (14.8)	0.097
Severe oxygen desaturation	1 (1.3)	0 (0)	0.494
Hypotension	52 (65.8)	27 (33.3)	0.001
Hypertension	0 (0)	0 (0)
Bradycardia	11 (13.9)	0 (0)	0.001
Tachycardia	1 (1.3)	0 (0)	0.494
Need for ephedrine	26 (32.9)	9 (11.1)	0.001
Need for phenylephrine	28 (35.4)	19 (23.5)	0.096
PONV	0 (0)	1 (1.2)	0.506
Pain	1 (1.3)	2 (2.5)	0.497
Bad mood state	1 (1.3)	1 (1.2)	0.745

Abbreviations: PONV, postoperative nausea and vomiting
Data are presented as mean ± SD, n (%), or median (IQRs), with the P-value representing the significance level for differences between groups A and E (Student’s t-test, Mann–Whitney U test, Pearson’s χ² test, or Fisher exact test)

ISSN: 1471-2253