Table 1 Summary of findings
From: The safety of remimazolam versus propofol in gastroscopic sedation: a meta-analysis
Certainty assessment | No. of patients | Effect | Certainty | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
No. of studies | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | remimazolam | propofol | Relative (95% CI) | Absolute (95% CI) | |
Respiratory depression | ||||||||||
10 RCTs | seriousa | not serious | not serious | not serious | strong association | 40/653 (6.1%) | 132/652 (20.2%) | RR 0.40 (0.28 to 0.57) | 121 fewer per 1,000 (from 146 to 87 fewer) | ⊕ ⊕ ⊕ ⊕ High |
Hypoxemia | ||||||||||
10 RCTs | seriousa | not serious | not serious | not serious | strong association | 35/629 (5.6%) | 118/610 (19.3%) | RR 0.34 (0.23 to 0.49) | 128 fewer per 1,000 (from 149 to 99 fewer) | ⊕ ⊕ ⊕ ⊕ High |
Bradycardia | ||||||||||
13 RCTs | seriousa | not serious | not serious | not serious | strong association | 27/843 (3.2%) | 84/824 (10.2%) | RR 0.34 (0.23 to 0.51) | 67 fewer per 1,000 (from 78 to 50 fewer) | ⊕ ⊕ ⊕ ⊕ High |
Dizziness | ||||||||||
7 RCTs | seriousa | not serious | not serious | not serious | strong association | 34/785 (4.3%) | 81/788 (10.3%) | RR 0.45 (0.31 to 0.65) | 57 fewer per 1,000 (from 71 to 36 fewer) | ⊕ ⊕ ⊕ ⊕ High |
Injection pain | ||||||||||
14 RCTs | seriousa | seriousb | not serious | not serious | very strong association | 30/735 (4.1%) | 369/736 (50.1%) | RR 0.06 (0.03 to 0.13) | 471 fewer per 1,000 (from 486 to 436 fewer) | ⊕ ⊕ ⊕ ⊕ High |
Nausea or vomiting | ||||||||||
15 RCTs | seriousa | not serious | not serious | not serious | none | 109/1393 (7.8%) | 145/1380 (10.5%) | RR 0.79 (0.62 to 1.00) | 22 fewer per 1,000 (from 40 to 0 fewer) | ⊕ ⊕ ⊕ ⊝ Moderate |
Hypotension | ||||||||||
18 RCTs | seriousa | seriousb | not serious | not serious | publication bias strongly suspected c; strong association | 189/1506 (12.5%) | 425/1487 (28.6%) | RR 0.36 (0.26 to 0.48) | 183 fewer per 1,000 (from 211 to 149 fewer) | ⊕ ⊕ ⊝ ⊝ Low |