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Table 2 Observed and PAVA-adjusted response rates

From: The 50% effective dose of hydromorphone and morphine for epidural analgesia in the hemorrhoidectomy: a double-blind, sequential dose-finding study

Assigned Dose, mg

No. Of Successes

No. Of Patients

Observed successful rates

PAVA-adjusted successful rates

Morphine

    

1

1

2

0.500

0.250

1.1

0

1

0.000

0.250

1.2

6

11

0.540

0.540

1.3

20

21

0.952

0.952

1.4

5

5

1.000

1.000

Hydromorphone

    

0.3

0

1

0.000

0.000

0.35

2

4

0.500

0.500

0.4

15

20

0.750

0.750

0.45

15

15

1.000

1.000

  1. PAVA = pooled-adjacent-violators algorithm
  2. ∗PAVA-adjusted response rates were estimated using the weighted isotonic regression method