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Table 3 Analysis of factors predicting ARDS in sepsis patients

From: LncRNA HOTTIP as a diagnostic biomarker for acute respiratory distress syndrome in patients with sepsis and to predict the short-term clinical outcome: a case-control study

Parameters

Univariate logistic regression

Multivariate logistic regression

HR

95%CI

P

HR

95%CI

P

Higher LnRNA HOTTIP

19.862

5.597–70.482

< 0.001

0.019

0.03–0.135

< 0.001

Higher Age

0.427

0.142–1.286

0.130

-

  

Gender

1.099

0.497–2.433

0.815

   

BMI (kg/m2)

0.746

0.338–1.649

0.469

   

Smoke

0.407

0.181–0.917

0.030

0.339

0.082–1.390

0.133

COPD

0.259

0.102–0.658

0.005

0.186

0.035–0.983

0.048

Cardiomyopathy

1.159

0.525–2.560

0.715

   

Chronic kidney failure

0.516

0.187–1.419

0.200

   

Cirrhosis

2.164

0.746–6.276

0.155

   

Abdominal infection

2.227

0.903–5.496

0.082

   

Respiratory infection

0.225

0.091–0.558

0.001

0.151

0.033–0.686

0.014

Skin and soft tissue infection

0.955

0.354–2.575

0.928

   

Bloodstream infection

2.260

0.469–10.896

0.310

   

CNS infection

0.835

0.146–4.785

0.840

   

Other infection

0.276

0.033–2.293

0.233

   

G−

0.888

0.400–1.970

0.770

   

G+

0.744

0.295–1.880

0.532

   

Anaerobes

0.640

0.194–2.114

0.464

   

Fungus

1.058

0.195–5.730

0.948

   

Mycoplasmas

1.722

0.186–15.976

0.633

   

Total culture negative

1.245

0.445–3.480

0.676

   

Higher Scr

1.629

0.735–3.606

0.229

   

Higher Albumin

1.330

0.596–2.965

0.486

   

Higher WBC

0.536

0.240–1.197

0.128

   

Higher CRP

0.334

0.145–0.771

0.010

0.220

0.057–0.853

0.029

Higher PCT

0.334

0.145–0.771

0.010

0.664

0.158–2.788

0.576

Higher IL-1β

0.338

0.144–0.791

0.012

0.260

0.056–1.201

0.084

Higher IL-6

0.563

0.252–1.256

0.160

   

Higher TNF-α

0.475

0.211–1.069

0.072

   

Higher APAHCE II score

2.961

1.264–6.934

0.012

0.364

0.095–1.404

0.142

Higher SOFA score

5.453

2.049–14.515

0.001

2.808

0.737–10.700

0.130

  1. BMI Body mass index, COPD Chronic obstructive pulmonary disease, CNS Central nervous system, APACHE Acute physiology and chronic health evaluation, SOFA Sequential organ failure assessment, Scr Serum creatinine, WBC White blood cells, CRP C-reactive protein, PCT Procalcitonin, TNF-α Tumor necrosis factor-α, IL Interleukin