Table 2 Comparison of characteristics between non-ARSD sepsis patients and ARDS sepsis patients

Demographics

 Age (year), mean ± SD

53.69 ± 10.92

56.20 ± 7.51

0.217

 Gender, n (%)

  Female

36 (43.37)

16 (45.71)

0.841

  Male

47 (56.63)

19 (54.29)

 BMI (kg/m²), mean ± SD

25.07 ± 2.42

26.07 ± 3.29

0.069

 Smoke, n (%)

25 (30.12)

18 (51.43)

0.037

Complications

 COPD, n (%)

11 (13.25)

13 (37.14)

0.005

 Cardiomyopathy, n (%)

35 (49.40)

16 (45.71)

0.841

 Chronic kidney failure, n (%)

11 (13.25)

8 (22.86)

0.272

 Cirrhosis, n (%)

22 (26.51)

5 (14.29)

0.230

Primary infection site

 Abdominal infection, n (%)

33 (39.76)

8 (22.86)

0.093

 Respiratory infection, n (%)

12 (14.46)

15 (42.83)

0.002

 Skin and soft tissue infection, n (%)

16 (19.28)

7 (20.00)

0.928

 Bloodstream infection, n (%)

10 (12.05)

2 (5.71)

0.506

 CNS infection, n (%)

4 (4.82)

2 (5.71)

0.840

 Other infection, n (%)

8 (9.64)

1 (2.86)

0.277

Primary organism

 G⁻, n (%)

45 (54.22)

20 (57.14)

0.841

 G⁺, n (%)

17 (20.48)

9 (25.71)

0.628

 Anaerobes, n (%)

8 (9.64)

5 (14.29)

0.524

 Fungus, n (%)

5 (6.02)

2 (5.71)

0.948

 Mycoplasmas, n (%)

4 (4.82)

1 (2.86)

0.629

 Total culture negative, n (%)

17 (20.48)

6 (17.14)

0.676

Biochemical indexes

 Scr (mg/dL), median (IQR)

1.9 (1.40, 2.7)

1.7 (1.4, 2.7)

0.641

 Albumin, (g/L), median (IQR)

27.2 (24.3, 31.0)

25.7 (23.8, 30.7)

0.284

 WBC (×10⁹/L), median (IQR)

16.5 (11.6, 27.2)

21.3 (14.6, 28.2)

0.060

 CRP (mg/L), median (IQR)

83.65 (58.80, 125.06)

165.07 (77.08, 255.97)

0.000

 PCT (ng/mL), median (IQR)

12.9 (8.9, 19.8)

18.8 (9.9, 28.7)

0.006

 Inflammatory cytokines

  IL-1β (pg/mL)

13.5 (7.6, 19.35)

13.9 (10.9, 22.8)

0.071

  IL-6 (pg/mL)

66.3 (34.7, 104.9)

78.4 (49.8, 162.1)

0.065

  TNF-α (pg/mL)

181.5 (142.8, 228.4)

202.9 (157.0, 240.7)

0.063

Disease severity

 APAHCE II score, median (IQR)

12.0 (8.0, 16.0)

15.0 (10.0, 18.0)

0.029

 SOFA score, median (IQR)

5.0 (4.0, 8.0)

7.0 (6.0, 10.0)

0.002