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Fig. 6 | BMC Anesthesiology

Fig. 6

From: LncRNA HOTTIP as a diagnostic biomarker for acute respiratory distress syndrome in patients with sepsis and to predict the short-term clinical outcome: a case-control study

Fig. 6

Targets genes of HOTTIP and bioinformatics analysis. A Veen diagram presenting target miRNAs predicted for HOTTIP in LncBook and DIANA databases. B Targeted binding site between HOTTIP and miR-574-5p. C Dual-luciferase reporter gene validates the targeting relationship between miR-574-5p and HOTTIP. D Serum miR-574-5p levels were assessed by the RT-qPCR. E Pearson’s correlation analysis was employed to examine the relationship between serum miR-574-5p levels and HOTTIP levels in patients with ARDS sepsis. F Veen diagram presenting multiple databases predicting overlapping target genes for miR-574-5p. G Veen’s diagram presented the overlapping genes between miR-574-5p targets genes and sepsis, ARDS-related genes, respectively. The biological function and pathway of the overlapping genes were identified through the bioinformatics platform, which makes use of GO (H) and KEGG (I) pathway (guidelines: www.kegg.jp/kegg/kegg1.html). ***P < 0.0001 vs. miR-NC, controls, or Non-ARDS sepsis

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BMC Anesthesiology

ISSN: 1471-2253

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