Plasma indole-3-aldehyde as a novel biomarker of acute kidney injury after cardiac surgery: a reanalysis using prospective metabolomic data

Table 2 Risk reclassification of postoperative AKI in cardiac surgery

Outcomes		Category-Free	P Value	Category-Free NRI				IDI (95% CI)	P Value
Outcomes		NRI (95% CI)	P Value	With Event	P value	Without Event	P value	IDI (95% CI)	P Value
AKI
	Clinical risk factors	Referent						Referent
	Clinical risk factors plus I3A	0.83 (0.36–1.29)	0.0005	19%	0.3275	64%	0.0000	0.09 (0.02–0.16)	0.0132

The established risk factors included age, APACHE II score, hemoglobin and cardiopulmonary bypass time. AKI, acute kidney injury; APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; IDI, integrated discrimination improvement; NRI, net reclassification improvement

ISSN: 1471-2253