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Table 1 NIV and MI-E training performed in outpatient setting before delivery

From: Peri-partum respiratory management of pregnant women with neuro-muscular disorders: a prospective observational study (IT-NEUMA-Pregn study)

NIV training

MI–E training

âś“ After a thorough explanation of the principles of NIV to the women, NIV was started during short, repetitive periods during the day

âś“ The patient was trained by a pulmonologist or an intensivist experienced in the use of NIV

âś“ The interface was either a nasal mask or a facial mask

âś“ The pressure setting was progressively increased, taking into account the comfort of the woman, to achieve a minimal tidal volume of 8 ml/kg with a good tolerance during at least 30 min period

✓ After a detailed description of the principles of MI-E, the patient was trained by a physiotherapist to the MI–E using a cough assist device where pressures are generated by a two-stage centrifugal blower

✓ Initial inspiratory and expiratory pressures of MI-E were set at a low level (+ 15/-15 cmH2O, respectively). Subsequently, the positive and negative pressures were progressively increased up to a maximum of 40 cmH2O

✓ During insufflation–exsufflation applications face mask, which was firmly applied on the patient’s face, was used

  1. NIV and MI–E training was carried out during a 1-day hospitalization in an outpatient setting, between 1 and 4 weeks prior to the delivery. At the end of the training trial, the patient was discharged home and was instructed to use the NIV with a minimum of 30 min per day, associated with at least one daily MI–E session
  2. NIV non-invasive ventilation, MI-E mechanical insuflator-exsufflator