Table 4 Adverse effects, administered drugs for treatment and patients` satisfaction score

Bradycardia; n, %

10 (10.0%)

6 (6.0%)

8 (8.0%)

#0.581

RR

95% CI

1.67

0.63–4.41

1.25

0.51–3.04

0.75

0.27–2.08

Hypotension; n, %

28 (28.0%) a

8 (8.0%) b

25 (25.0%) a

#< 0.001*

RR

95% CI

3.50

1.68–7.30

1.12

0.71–1.78

0.32

0.15–0.67

Patients in need for ephedrine; n, %

75 (75.0%) a

36 (36.0%) b

72 (72.0%) a

#< 0.001*

RR

95% CI

2.08

1.57–2.77

1.04

0.88–1.23

0.50

0.37–0.67

Ephedrine dose; (mg)

23.7 (3.4.0%) a

13.9 (3.2.0%) b

22.5 (3.8.0%) a

^< 0.001*

M (SE)

95% CI

9.9 (0.7)

8.5–11.2

1.3 (0.6)

0.1–2.4

−8.6 (0.7)

−10.1–-7.1

Pruritus; n, %

7 (7.0%) a

9 (9.0%) a

26 (26.0%) b

#< 0.001*

RR

95% CI

0.78

0.30–2.01

0.27

0.12–0.59

0.35

0.17–0.70

Nausea; n, %

9 (9.0%) a

6 (6.0%) a

27 (27.0%) b

#< 0.001*

RR

95% CI

1.50

0.55–4.06

0.33

0.17–0.67

0.22

0.10–0.51

Vomiting; n, %

5 (5.0%) a

3 (3.0%) a

16 (1.0%) b

#< 0.001*

RR

95% CI

1.67

0.41–6.79

0.31

0.12–0.82

0.19

0.06–0.62

Patients in need for rescue antiemetic; n, %

6 (6.0%) a

3 (3.0%) a

24 (24.0%) b

#< 0.001*

RR

95% CI

2.00

0.51–7.78

0.25

0.11–0.59

0.13

0.04–0.40

Sedation Grade I; n, %

100 (100.0%)

100 (100.0%)

100 (100.0%)

Headache; n, %

5 (5.0%)

7 (7.0%)

8 (8.0%)

#0.687

RR

95% CI

0.71

0.23–2.18

0.63

0.21–1.84

0.88

0.33–2.32

Patients` Satisfaction Score

5.1 (0.7) a

5.0 (0.8) a

2.5 (0.6) b

^< 0.001*

M (SE)

95% CI

0.1 (0.1)

−0.1–0.3

2.6 (0.1)

2.4–2.8

2.5 (0.1)

2.3–2.7