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Table 2 Summary of TE arrhythmias in overall population. All Participants as Treated

From: A randomized trial evaluating the safety profile of sugammadex in high surgical risk ASA physical class 3 or 4 participants

Treatment

n (%)

Difference in %a (95% CI)

P-value

TE Sinus Bradycardia

 Neostigmine/glycopyrrolate, n = 51

4 (7.8)

(ref.)

 

 Sugammadex 2 mg/kg, n = 105

1 (1.0)

− 6.7 (− 17.5, − 0.8)

0.026

 Sugammadex 4 mg/kg, n = 107

2 (1.9)

− 6.2 (− 17.3, 0.2)

0.058

 Sugammadex 16 mg/kg, n = 68

5 (7.4)

− 2.0 (− 17.8, 8.6)

0.730

TE Sinus Tachycardia

 Neostigmine/glycopyrrolate, n = 51

11 (21.6)

(ref.)

 

 Sugammadex 2 mg/kg, n = 105

7 (6.7)

− 14.9 (− 28.8, − 4.0)

0.007

 Sugammadex 4 mg/kg, n = 107

10 (9.3)

− 12.2 (− 26.1, − 0.8)

0.036

 Sugammadex 16 mg/kg, n = 68

6 (8.8)

− 9.9 (− 27.6, 3.6)

0.158

Other TE Cardiac Arrhythmias

 Neostigmine/glycopyrrolate, n = 51

1 (2.0)

(ref.)

 

 Sugammadex 2 mg/kg, n = 105

1 (1.0)

−0.9 (− 9.4, 4.0)

0.637

 Sugammadex 4 mg/kg, n = 107

0

− 2.1 (− 10.6, 1.5)

0.134

 Sugammadex 16 mg/kg, n = 68

1 (1.5)

−1.7 (− 14.7, 5.8)

0.577

  1. aDifferences are calculated using the stratified Miettinen and Nurminen method with NMBA and ASA Physical Class strata as factors. ASA American Society of Anesthesiologists, CI Confidence interval, TE Treatment-emergent