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Table 3 Time courses of IL-17, IL-10 and their ratios among groups

From: Immunomodulatory effects of intraoperative dexmedetomidine on T helper 1, T helper 2, T helper 17 and regulatory T cells cytokine levels and their balance: a prospective, randomised, double-blind, dose-response clinical study

 

Group S

Group HD

Group FD

(n = 24)

(n = 26)

(n = 25)

IL-17 (pg/ml)

 T0

71.5

(9.8, 211.5)

77.6

(2.8, 229.2)

58.4

(21.8, 104.6)

 T1

70.1

(23.4, 131.1)

190

(51.6, 326.1)

118

(8.1, 387.4)

 T2

23.2

(7.1, 38.8)

116

(11.6, 280.4)

80.6

(38.1, 108.1)

IL-10 (pg/ml)

 T0

101

(10.1, 241.0)

97.6

(7.1, 210.6)

128

(21.6, 288.4)

 T1

120

(24.7, 258.1)

106

(4.9, 221.7)

28.2

(1.9, 56.5)*†

 T2

75.3

(1.2, 210.2)

85.4

(36.1, 228.5)

26.5

(1.3, 68.1)*

IL-17/IL-10

 T0

0.7

(0.2, 2.1)

0.8

(0.2, 2.2)

0.5

(0.1, 0.7)

 T1

0.6

(0.2, 0.8)

1.8

(0.2, 5.8)

4.2

(2.1, 9.6)*†

 T2

0.3

(0.1, 0.5)

1.4

(0.2, 2.7)†

3.0

(0.9, 4.5)*†

  1. Values are median with quartiles (25, 75%)
  2. T0, after induction of anaesthesia (baseline); T1, at the end of surgery;
  3. T2, 1 h after surgery at postanaesthetic care unit
  4. *, P < 0.05 vs. T0; †, P < 0.05 vs. group S
  5. S saline, HD half dose, FD full dose