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Table 2 Time courses of IFN-gamma, IL-4 and their ratios among groups

From: Immunomodulatory effects of intraoperative dexmedetomidine on T helper 1, T helper 2, T helper 17 and regulatory T cells cytokine levels and their balance: a prospective, randomised, double-blind, dose-response clinical study

 

Group S

Group HD

Group FD

(n = 24)

(n = 26)

(n = 25)

IFN-gamma (pg/ml)

 T0

74.2

(2.2, 141.4)

88.4

(1.6, 250.1)

87.6

(28.1, 219.3)

 T1

18.8

(1.8, 48.7)*

126

(36.3, 278.7)†

203

(51.0, 386.5)†

 T2

11.5

(1.3, 45.5)*

125

(10.6, 400.5)†

210

(41.6, 503.4)†

IL-4 (pg/ml)

 T0

81.6

(21.6, 145.5)

90.9

(20.7, 250.1)

91.6

(30.1, 223.4)

 T1

80.7

(13.3, 209.6)

67.2

(1.4, 231.3)

20.1

(2.3, 66.7)*

 T2

98.9

(26.5, 217.2)

30.1

(1.9, 99.3)

28.4

(1.2, 108.7)*

IFN-gamma/IL-4

 T0

0.9

(0.2, 2.6)

1.0

(0.2, 1.9)

1.0

(0.3, 1.3)

 T1

0.2

(0.1, 0.6)*

1.9

(0.2, 6.4)†

10.1

(3.5, 15.1)*†‡

 T2

0.1

(0.0, 0.3)*

4.1

(1.1, 10.4)*†

7.4

(0.8, 21.8)*†

  1. Values are median with quartiles (25, 75%)
  2. T0, after induction of anaesthesia (baseline); T1, at the end of surgery;
  3. T2, 1 h after surgery at postanaesthetic care unit
  4. *, P < 0.05 vs. T0; †, P < 0.05 vs. group S;
  5. ‡, P < 0.05 vs. group HD
  6. S saline, HD half dose, FD full dose
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BMC Anesthesiology

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